Melanotan are powerful non-selective agonists receptor melanocortin (MC) with high affinity to receptor subtypes, MC1, MC3, MC4 and MC5. Their endogenous contrasts, melanocortin peptides, help regulate a range of physiological systems, including pigmentation system, energy homeostasis, sexual function, immune system, inflammation and cardiovascular system. Melanotan 2 was developed to treat sexual dysfunction, but it is currently being considered as a treatment for hemorrhagic shock.
Most people use Melanotan to obtain a cosmetic tan and speed up the process of weight loss. Under the influence of ultraviolet (UV) exposure α-MSH, melanin production from melanocytes in the skin is stimulated. Melanin is a brown pigment and is responsible for the sunburn of the skin.
Simply put, more α-MSH – means more melanin, which leads to increased pigmentation of the skin. Since in bodybuilding from an aesthetic point of view, darker skin is welcome, which emphasizes muscles, it is not surprising that these drugs are in great demand.
Currently analogues based on melanotan 1 and 2 undergo clinical trials. These synthetic versions of α-MSH were developed at the University of Arizona in the 1980s. Australian company Clinuvel Pharmaceuticals Limited has the right to sell MT (CUV1647), and their target audience – people with adverse reactions to UV radiation.
This includes those who have observed polymorphic light eruption (PLE PMLE) and actinic keratosis (AK), when the skin does not tolerate UV, and the reaction is characterized by strong ulcers, itching, burning, or dry damage. You might think this peptide would be the perfect treatment for albinos.
However, these individuals generally have no shortage of α-MSH, but instead have zero binding of the melanocyte receptor. Therefore, simply increasing the level of circulation of α-MSH or its analogues is useless. The Company Palatin Technologies Inc., based in the US, instead focused on the analogue of the MT-II. It is licensed as Bremelanotide (formerly PT-141). The direction is a sexual dysfunction, more specifically erectile dysfunction (ED) in men.
The effects of Melanotan
Both Melanotan and Melanotan 2 have been shown an increase in pigmentation without exposure to ultraviolet radiation. This effect is confirmed by those who used the substance. They observed the tan in areas of the body, which are almost not exposed to sunlight.
In addition, the tanning process is significantly accelerated by exposure to ultraviolet radiation. But, unfortunately, the effect of a sunburn may not be uniform throughout the skin. This is due to the half-lives and the spread of the drug in certain areas of the skin.
Most people will notice the greatest effect of sunburn on the face, hands, abdomen. Interestingly, genitals have one of the highest concentrations of melanocytes, which allows these specific areas to respond well to the peptide in combination with UV radiation.
Melanotan 2, 1 – dosage and side effects
In clinical trials, doses up to 0.21 mg / kg per day for Melanotan 1 (16 mg for a 75 kg person) and up to 0.03 mg / kg daily for Melanotan 2 (2.25 mg for 75 kg) were used to determine peptide efficacy. At this dosage level, the study revealed the following cases of side effects:
- Nausea 85%
- Facial redness 75%
- Fatigue 44%
- Vomiting 26%
- Reactions to injections 13%
Changes in vital signs or hematological parameters, blood biochemistry (liver and kidney function), as side effects of Melanotan have not been seen.
Both Melanotan and Melanotan 2 can be used for long periods, resulting in an initial daily administration of 2-3 weeks or until the desired pigmentation level is reached. Then follows the maintenance phase of two injections per week.
Start with a dose of 1 mg per day for the first two or three days, and if the level of side effects will allow, increase the dosage by 0.25 mg every day for the next few days until you reach a daily dose of 2-3 mg. This level should be sufficient for most people, although some may wish to increase the dose to achieve a very deep tan. The maintenance phase is then used as described above.
Start with a dose of 0.25 mg. If side effects (primarily nausea) do not bother, try to increase your daily dose by 0.25 mg until you reach 1-1.5 mg a day. As with Melanotan, the maintenance phase is used after reaching the desired level. Melanotan 2 can only cause harm in the form of a very strong tan, and only at a significant dose excess.
Preparation and administration of Melanotan
Melanotan is currently supplied as a white lyophilized powder contained in a sealed reusable bottle. To prepare for the injection, the powder must be diluted with bacteriostatic water. Depending on the amount of water used, the concentration of your solution will be determined.
Example of solution: 10 mg of Melanotan 2 powder with 4 ml bacteriostatic water (10 mg / 4 ml or 1 mg / 0.4 ml or 0.25 mg / 0.1 ml).
The injection is injected into the subcutaneous layer, which includes adipose tissue (fat). If you use insulin syringes with short needles, you need to enter it into the skin at an angle of 90°.